Does sermorelin stop muscle loss on a GLP-1?

It hasn't been shown to. One six-week study found no change in lean mass or fat. The reviewed evidence does not establish that adding sermorelin to a GLP-1 protects muscle. Training and protein are the levers with trial support.

How do I keep muscle while losing weight?

Resistance training plus enough protein. A meta-analysis of 49 trials found protein added to the gains from lifting. A dietitian or prescriber can set a protein target that fits your appetite.

Can I get testosterone just to keep muscle?

FDA labels cover men with low testosterone from a diagnosed cause, confirmed with blood tests. If your levels are normal, it isn't labeled for you. A prescriber makes that call after labs.

Does the card price include my weight-loss medicine?

No. On this page each card shows the provider's monthly price for sermorelin or testosterone. A GLP-1, if you take one, is a separate prescription with its own price.

Back to the full body composition list

Keeping muscle while losing weight: the shortlist

By Peptide Clarity Guide · October 2026

12 providers that offer sermorelin or testosterone made the shortlist, at $100 to $216 a month. 25 more offer it but aren't picks yet, and the rule each one misses sits by its name.

Who's on it: providers that are In on the body composition list and prescribe sermorelin or testosterone. Listed in pick order.

We may earn a commission through qualifying provider links at no extra cost to you. Read our selection criteria and funding disclosure. How we earn

Partners on this list

Partner cards: if you join through one, the provider pays us a fee and your price stays the same. The full list below keeps its pick order.

Strut HealthPartner
Sermorelin sublingual$100.38/mo
Visit Strut Health Read the pick

Made the shortlist

Listed in pick order. See how picks work.

Top pick
Goldspan Health
Sermorelin injections or men's TRT, from a clinician-run catalog.
Testosterone$137.96/mo
Visit Goldspan Health
Strut HealthPartner
Sermorelin as a shot or under the tongue, with doctor messaging.
Sermorelin sublingual$100.38/mo
Visit Strut Health
HealthRX
Testosterone injections or cream, or sermorelin after a clinician review.
Sermorelin$179/mo
Visit HealthRX
Precision Telemed
TRT with labs and physician oversight, or sermorelin shipped cold-chain.
Sermorelin$179.99/mo
Visit Precision Telemed
PauseRx
Testosterone cream or sermorelin, with labs before anything is prescribed.
Testosterone cream$199/mo
Visit PauseRx
Prime Doctor RX
Testosterone care that starts with labs, or sermorelin under one intake.
TestosteronePrice on request
Visit Prime Doctor RX
Brightmeds
Men's TRT with the blood test and doctor visit included, or sermorelin monthly.
Sermorelin$129/mo
Visit Brightmeds
AgelessRx
Sermorelin nasal spray from a clinic that also runs labs and live visits.
Sermorelin nasal spray$199/mo
Visit AgelessRx
TeleZen MD
Sermorelin shots billed monthly or quarterly, after an online review.
Sermorelin$205.92/mo
Visit TeleZen MD
Luvo Health
Sermorelin shots on a 4-week price that includes the clinician review.
Sermorelin$216.18/mo
Visit Luvo Health
Gala GLP-1Partner
Sermorelin at home after clinician review; confirm the selected refill agreement.
SermorelinPrice on request
Visit Gala GLP-1
Lttl
Sermorelin shots with clinician messaging and refills inside the plan price.
SermorelinPrice on request
Visit Lttl

Not a pick yet

Arc-1 Not yet
Why: Prints no cancellation terms for its monthly subscriptions.
When the gap closes, Arc-1 can move to In.
Read the pick
BioGlow Health Not yet
Why: Approximate month-supply prices do not establish automatic refill charges or dates.
When the gap closes, BioGlow Health can move to In.
Read the pick
bmiMD Not yet
Why: Terms describe twenty-eight-to-thirty-day renewal and separate quarterly billing.
When the gap closes, bmiMD can move to In.
Read the pick
Bodybuilding Health+ Not yet
Why: Lists Strive Pharmacy but not which Strive site fills your order.
When the gap closes, Bodybuilding Health+ can move to In.
Read the pick
Defy Medical Not yet
Why: Medication, testing and consultation costs require an itemized personalized quote.
When the gap closes, Defy Medical can move to In.
Read the pick
DirectMeds Not yet
Why: Its BPC-157 listing does not meet the reviewed routine commercial compounding conditions.
When the gap closes, DirectMeds can move to In.
Read the pick
DudeMeds Not yet
Why: The reviewed disclosures do not identify the pharmacy filling the selected order.
When the gap closes, DudeMeds can move to In.
Read the pick
EdgeRx Not yet
Why: Names Strive Pharmacy as its one pharmacy, but not which Strive site ships.
When the gap closes, EdgeRx can move to In.
Read the pick
ElitePhysiqMD Not yet
Why: Its investigational peptide catalog leaves the qualifying access pathway unclear.
When the gap closes, ElitePhysiqMD can move to In.
Read the pick
ElleS Not yet
Why: The actual dispensing site and selected payment and refund agreement need confirmation.
When the gap closes, ElleS can move to In.
Read the pick
Embody Not yet
Why: Confirm the current renewal amount and charge interval before comparing plans.
When the gap closes, Embody can move to In.
Read the pick
Fridays Not yet
Why: TRT medication is extra; GLP-1 promotional totals need a selected renewal quote.
When the gap closes, Fridays can move to In.
Read the pick
GoodLife Health Not yet
Why: Medication is billed by the pharmacy, and no monthly drug price is published.
When the gap closes, GoodLife Health can move to In.
Read the pick
KIN Meds Not yet
Why: Starting hormone offers do not settle the selected form, testing and recurring total.
When the gap closes, KIN Meds can move to In.
Read the pick
MangoRx Not yet
Why: The TRT testing offer and laboratory costs leave the full medication renewal unclear.
When the gap closes, MangoRx can move to In.
Read the pick
Next Vial Not yet
Why: Starting offers and differing GLP-1 pages leave selected renewal charges unconfirmed.
When the gap closes, Next Vial can move to In.
Read the pick
Nova Not yet
Why: Prescribing-decline fees and medication and membership charges need clarification.
When the gap closes, Nova can move to In.
Read the pick
Oak Not yet
Why: Lists tesamorelin without saying whether it's the brand drug or compounded.
When the gap closes, Oak can move to In.
Read the pick
PeterMD Not yet
Why: Confirm the dispensing facility, current authorization and actual recurring agreement.
When the gap closes, PeterMD can move to In.
Read the pick
RNK Health Not yet
Why: Inclusive-price claims differ from terms allowing separate pharmacy fees.
When the gap closes, RNK Health can move to In.
Read the pick
Science & Co Not yet
Why: Annual headlines do not establish the selected ongoing invoice and charge interval.
When the gap closes, Science & Co can move to In.
Read the pick
SkinnyRx Not yet
Why: Current introductory GLP-1 offers do not establish the later renewal charge.
When the gap closes, SkinnyRx can move to In.
Read the pick
System Labs Not yet
Why: Homepage and product offers differ; crossed-out figures do not establish renewal.
When the gap closes, System Labs can move to In.
Read the pick
Wellorithm Not yet
Why: Monthly pricing and twenty-eight-day terms describe different renewal schedules.
When the gap closes, Wellorithm can move to In.
Read the pick
WePeptideRx Not yet
Why: Dose-selector prices differ from the same product page’s overview.
When the gap closes, WePeptideRx can move to In.
Read the pick

Who's on this list, and the honest caveat

Here's the short version. The qualifying picks on the body composition list offer sermorelin or testosterone, the two treatments people ask about most when they want to hold on to muscle while losing weight. The price on each card is for that sermorelin or testosterone product. Your weight-loss medicine, if you take one, is billed on its own.

Now the caveat. Neither treatment has been shown to protect muscle during weight loss. The two things with real trial support are lifting and eating enough protein. So read this page as a list of places to ask about a hormone, after the basics are in place, not as a muscle fix.

What weight loss does to muscle

Some of the weight you lose on any diet or drug is lean mass. In a body-scan substudy of the main tirzepatide trial, fat fell 33.9% and lean mass 10.9% over 72 weeks. About three quarters of the loss was fat, the same split the placebo group showed.

For semaglutide, a 2024 review of GLP-1 trials found the lean share swung widely, from about 15% of weight lost in some studies to 40% to 60% in others. Who was studied explained much of the gap.

One more thing to know: "lean mass" on a DXA scan includes organs and water; bone mineral is reported separately. An MRI analysis from the STEP UP semaglutide trial found the thigh-muscle drop wasn't statistically clear, fat inside the muscle fell, and sit-to-stand scores went from 13 to 15. It was a small secondary analysis, so it cannot establish that every patient preserves muscle or strength.

What actually protects muscle

Resistance training. Weights, machines or bodyweight work give muscle a reason to stay while you eat less. It is a practical starting point to discuss with your clinician.

Enough protein. A 2018 meta-analysis of 49 trials in 1,863 adults found that adding protein to resistance training raised fat-free mass gains by 0.66 lb (0.30 kg) and one-rep strength by 5.5 lb (2.49 kg). The boost was smaller with age.

Those trials weren't in people on a GLP-1 drug, and a smaller appetite can make protein harder to hit. A dietitian or your prescriber sets the target that fits you. This page doesn't give one.

If you're on tirzepatide, whether you can build muscle on tirzepatide goes deeper. On semaglutide, see building muscle on Ozempic.

Where sermorelin fits

Sermorelin prompts the pituitary to release more growth hormone. One small study followed 11 older men for six weeks. DEXA scans showed no change in lean mass or fat, and IGF-1 did not rise. Other GHRH studies used different populations and protocols; they do not establish muscle preservation during GLP-1 treatment.

A related drug, tesamorelin, added under a tenth of a square inch of trunk muscle area in a narrow group of adults with HIV. Tesamorelin is not sermorelin. Its approved HIV indication and separate clinical evidence do not establish a benefit from a compounded sermorelin product.

The reviewed evidence does not establish a benefit from combining sermorelin with tirzepatide, and blood sugar is the open question: one lowers it, while growth hormone can raise it. Sermorelin and tirzepatide together covers what to ask, and does sermorelin build muscle has the study detail.

Where testosterone fits

Testosterone is an FDA-approved, Schedule III hormone labeled for adult men with low testosterone from a diagnosed cause, confirmed by morning blood tests on two separate days. If your levels are normal, TRT isn't labeled for you, whatever your training goal. Once you start, labels call for regular checks of red blood cell levels, PSA and blood pressure.

In the Testosterone Trials, a year of gel in 790 men aged 65 and up helped sex drive and mood modestly, but the physical-function trial missed its walking goal. That's not a muscle-building result.

TRT also slows your own production and can suppress sperm. The full picture is in TRT explained.

How you'll know it's working

A bathroom scale can't tell muscle from fat. Strength is the practical signal: if your lifts hold steady or climb while the weight comes off, you're likely keeping muscle.

A body-composition scan gives a clearer picture. Ask your prescriber whether one is worth paying for before you book it. If you're over 65 or recovering from an illness, ask how they'll track strength at each visit, for example with a chair-stand or grip test.

Choosing from these cards

Two prescriptions, two prices. A hormone is a second treatment with its own labs and its own monthly cost. Add it to your weight-loss plan when you budget.

Labs first. Testosterone products here usually need bloodwork before the first order. For sermorelin, ask for an IGF-1 baseline.

Fees. A lab fee, a visit fee or a membership applies at a few providers. The card names it when it's required.

One prescriber. If you're on a GLP-1, it's simpler when the same clinician sees both prescriptions. Ask whether the program can manage the pair.

The first conversation. A good program asks how you train and how you eat before it adds a hormone. If nobody asks, bring it up yourself.

Questions about this list

Does sermorelin stop muscle loss on a GLP-1?: It hasn't been shown to. One six-week study found no change in lean mass or fat. The reviewed evidence does not establish that adding sermorelin to a GLP-1 protects muscle. Training and protein are the levers with trial support.
How do I keep muscle while losing weight?: Resistance training plus enough protein. A meta-analysis of 49 trials found protein added to the gains from lifting. A dietitian or prescriber can set a protein target that fits your appetite.
Can I get testosterone just to keep muscle?: FDA labels cover men with low testosterone from a diagnosed cause, confirmed with blood tests. If your levels are normal, it isn't labeled for you. A prescriber makes that call after labs.
Does the card price include my weight-loss medicine?: No. On this page each card shows the provider's monthly price for sermorelin or testosterone. A GLP-1, if you take one, is a separate prescription with its own price.

This is general information, not medical advice. A licensed clinician can tell you what fits you. Health note